Point of care testing: lateral flow technology and beyond

A glass fiber sheet-based electroosmotic lateral flow immunoassay for point-of-care testing.

We have developed a quantitative immunoassay chip targeting point-of-care testing. To implement a lateral flow immunoassay, a glass fiber sheet was chosen as the material for the microfluidic channel in which the negative charge on the fiber surfaces efficiently generates the electroosmotic flow (EOF). The EOF, in turn, allows controllable bound/free separation of antigen/antibody interactions ...

Point-of-care Blood Coagulation Monitoring Using Lateral Flow Device

A simple and affordable method of evaluating blood coagulation ability using microfluidic paperbased lateral flow assay (LFA) device is reported. Rabbit whole blood treated with citrate as anticoagulant was used in experiments. Re-establishment of blood coagulation cascade and creation of different coagulation abilities were achieved by adding CaCl2 solutions of varying concentrations. Since vi...

Lateral flow tests for allergy diagnosis: point-of-care or point of contention?

developed for detection of allergen-specific IgE and could have utility for allergy diagnosis. However, it is only recently that an allergy diagnostic LFT has been introduced to practice. In this issue, Sanchez-Bahillo et al. [6] compare the performance of an allergy diagnostic LFT (ImmunoCAP Rapid, Phadia, Sweden) with skin prick testing in a cohort of allergic children from Cartagena (Spain) ...

Correlation between Standard Clinical Chemistry and Point of Care Testing Analyzers on Hemoglobin A1C Determination

Point-of-care testing for coeliac disease: primary care diagnostic technology update

British Journal of General Practice, June 2013 e426 BaCkground and advantages over exIstIng teChnology Coeliac disease is a malabsorption syndrome precipitated by gluten ingestion, and characterised by inflammation of the small intestine. Serological tests for IgA anti-tissue transglutaminase antibody (tTGA) and anti-endomysial antibody (EMA) have high sensitivity and specificity for coeliac di...